Del Rio, Phillips back in head coaching roles
Denver (7-1) at San Diego (4-4)
Chargers coach Mike McCoy, who called plays for Peyton Manning last season, gets a chance to beat his former team.
The Broncos are coming off their bye week. Before that, they scored the last 38 points in beating Washington 45-21 as Manning overcame four turnovers to throw for 354 yards and four touchdowns.
The Chargers are coming off a 30-24 overtime loss at Washington in which they had three shots at the end zone from the 1-yard line in the closing seconds but failed to score a touchdown.
Houston (2-6) at Arizona (4-4)
Case Keenum gets his third straight start at quarterback for Houston, which despite its losing record, enters the game first in the NFL in defense and eighth in offense.
The Texans, who have lost six straight, have never dropped seven in a row.
Arizona rookie running back Andre Ellington leads the NFL at 7.7 yards per carry for players with a minimum of 40 attempts.
Detroit (5-3) at Chicago (5-3)
In a matchup between two of the three teams tied for the NFC North lead, the Bears get quarterback Jay Cutler back earlier than expected from a torn groin sustained Oct. 20.
The Bears had a bye after their 45-41 loss to Washington, which provided some extra time for Cutler to recover. The Lions, who haven’t won at Soldier Field since 2007, will go for a season sweep against the Bears after beating them in September.
Philadelphia (4-5) at Green Bay (5-3)
The Packers hope to keep pace in the NFC North race without Aaron Rodgers, expected to miss the game after hurting his collarbone in Monday night’s loss to Chicago. Seneca Wallace will likely get the nod for Green Bay, which will rely on running backs Eddie Lacy and James Starks.
The Eagles don’t have the same quarterback questions. Nick Foles, coming off a record-tying seven touchdown passes against the Raiders, should start for Philadelphia.
Carolina (5-3) at San Francisco (6-2)
The 49ers have won five straight since dropping two in a row in Weeks 2 and 3, scoring 31 or more points in each of those victories.
Cam Newton and the Panthers are unbeaten in their past four games and have scored 30 or more points in their five wins. Carolina trails first-place New Orleans by one game in the NFC South.
Dallas (5-4) at New Orleans (6-2)
Tony Romo and Drew Brees could put up plenty of points in this prime-time matchup. Saints defensive coordinator Rob Ryan will be trying to stop Romo, going against the club that fired him last season.
The Saints have won 11 straight in the Superdome at night, including playoff games. The last time New Orleans lost a night game at home was Dec. 19, 2009 — against Dallas.
Cincinnati (6-3) at Baltimore (3-5)
The Bengals, who will play their first full game without All-Pro defensive lineman Geno Atkins, can take a big step toward winning the AFC North with a victory at the Super Bowl champs. Starting today, the Ravens play four of their next five games at home.
Oakland (3-5) at New York Giants (2-6)
The Giants, coming off a bye, have won two in a row and start a stretch of three consecutive home games.
Eli Manning will be facing a Raiders secondary that gave up a record-tying seven touchdown passes last week to the Eagles. And the Giants’ defense has not given up a touchdown in 10 quarters, going back to the second period of a game against Chicago on Oct. 10.
Jacksonville (0-8) at Tennessee (4-4)
The Titans became the first team to lose to the previously winless Colts in 2011, a defeat that kept the Titans out of the playoffs by virtue of a tiebreaker. In 2012, Tennessee became the first team to lose in Jacksonville and dropped four of its final six while slumping to a 6-10 finish.
For the Jaguars, receiver Justin Blackmon was given an indefinite suspension last week for violating the NFL’s substance-abuse policy.
St. Louis (3-6) at Indianapolis (6-2)
This matchup features two of the top sack leaders in the NFL.
The Colts’ Robert Mathis leads the NFL with 11½ sacks. St. Louis’ Robert Quinn leads the NFC with 10, Chris Long is in the conference’s top 10 with 5½ and the Rams are tied for third in the NFL with 29 sacks. Still, they have lost three straight.
Seattle (8-1) at Atlanta (2-6)
The Falcons, who started the season with Super Bowl aspirations, hope to pull an upset against one of the top teams in the league.
But Atlanta will need better play from quarterback Matt Ryan, who has thrown seven interceptions over the past two weeks.
Buffalo (3-6) at Pittsburgh (3-6)
The Steel Curtain couldn’t handle Tom Brady and the Patriots last week as the Steelers allowed 55 points and 610 yards. But this week they face Bills rookie quarterback EJ Manuel, expected to return after missing four games with a sprained right knee.
Five of Pittsburgh’s six losses have been by seven points or more.
Miami (4-4) at Tampa Bay (0-8), Monday night
The Dolphins are dealing with the distractions caused by the Jonathan Martin and Richie Incognito saga. The Buccaneers, meanwhile, are looking for their first victory of the season after blowing a 21-0 lead at Seattle last week.
— The Associated Press