New Orleans
With his 15th 400-yard game, Brees broke a tie with Peyton Manning for the most in the regular season.
Brees also led the Saints (2-3) to a second straight victory while Carolina lost its fourth straight despite the return of quarterback Cam Newton, who missed last week’s loss to Tampa Bay because of a concussion.
Newton passed for 322 yards and two touchdowns. He also ran for a 2-yard score and threw a 2-point conversion to Devin Funchess that tied the game at 38 with 2:58 left, and completed a comeback from an early 21-0 deficit.
However, he was also intercepted by Sterling Moore in the back of the end zone, stalling a promising drive in the first half — a turnover that came back to haunt the defending NFC champions, now 1-5.
Green Bay, Wis.
Prescott was 18-of-27, shaking off two fumbles and an interception — the first of his career — to lead the Cowboys (5-1) to their fifth straight win. He showed poise in the fourth quarter while marching the Cowboys on a seven-play, 75-yard drive that ended with a 4-yard touchdown pass to Cole Beasley for an 18-point lead.
The score left Packers fans stunned at Lambeau Field. They were booing at times following another choppy game for the offense. The four turnovers were a season high for Green Bay (3-2).
Seattle
After watching Matt Ryan blitz the Seahawks for 21 third-quarter points, it was Wilson’s turn in the fourth quarter. He led a 70-yard drive that was capped by Christine Michael’s 1-yard run with 4:47 left, but a blocked extra point by Ra’Shede Hageman still had Seattle trailing 24-23.
Seattle then got a needed big play from its defense. Ryan’s pass slipped through Julio Jones’ hands, was tipped in the air by Richard Sherman and eventually landed in the arms of Earl Thomas, giving Seattle possession at midfield with 3:48 remaining. It was the first time in the game that Jones was targeted and didn’t make the catch.
Oakland, Calif.
In their first game since getting blown out by 29 points in Pittsburgh two weeks ago, the Chiefs (3-2) efficiently handled a Raiders team that had overcome defensive shortcomings with a big-play offense to lead the AFC West.
Smith completed 19 of 22 passes for 224 yards, Jamaal Charles and big defensive lineman Dontari Poe each ran for scores, and the Chiefs forced two turnovers by Derek Carr to dampen a fast start to the season by the Raiders (4-2), who are trying to end a 13-year playoff drought.
Landover, Md.
The three-headed running attack of Matt Jones, Robert Kelley and Chris Thompson combined for 231 yards and a touchdown as the Redskins (4-2) won their fourth consecutive game. After starting the season 0-2, Washington has its best record through six games since 2008, when it went 8-8.
The Redskins put up 493 offensive yards against the Eagles (3-2), who came in allowing an average of 266.8 yards and 12.6 points as the league’s second-best defense. Cousins connected with Jamison Crowder on a 16-yard touchdown and with Vernon Davis on a 13-yarder.
Davis started at tight end in place of Jordan Reed, who was out with a concussion. Jones ran for a 1-yard touchdown and sealed the victory with a 57-yard run as part of his 135-yard day.
Miami Gardens, Fla.
Jay Ajayi rushed for 204 yards and two scores on 25 carries for the Dolphins (2-4).
The Steelers (4-2) had scored 74 points in their previous two games, but were outgained 474-297. Pittsburgh’s Antonio Brown, the NFL’s leading receiver, was held to four receptions for 39 yards. Teammate Sammie Coates, playing with a hand injury, didn’t have a catch.
Orchard Park, n.y.
Tyrod Taylor threw two touchdown passes in helping Buffalo (4-2) win four straight for the first time since the start of the 2008 season.
East Rutherford, n.j.
The win was the 700th in franchise history. Beckham gave it to the Giants with a career day despite going to the locker room with a hip pointer in the second quarter. Beckham returned before the half and made the Giants (3-3) a winner with a spectacular second half. It featured a 75-yard touchdown catch and a 43-yard reception that set up one of Josh Brown’s two field goals.
Detroit
The Rams (3-3) have lost two straight.
Case Keenum completed a Rams-record 19 straight passes, but couldn’t connect with Lance Kendricks on the long throw that Bush stepped in front of near midfield. Keenum finished 27 of 32 for 321 yards with three touchdowns — two to Kenny Britt, one to Kendricks — and an interception.
Nashville, Tenn.
The Titans (3-3) matched their win total for all of last season when they went 3-13 and wound up with the No. 1 draft pick overall. They also beat a team other than Jacksonville on their own field for the first time since the 2013 season finale and improved to 3-16 in Nashville.
Cleveland (0-6) is mired in its worst start since 1999 when the Browns lost their first seven as an expansion franchise.
Chicago
The Jaguars (2-3) wiped out a 13-0 deficit in the fourth quarter in a matchup of last-place teams. And the go-ahead touchdown might have been helped by the oft-criticized turf at Soldier Field.
Benn slipped as he caught a slant and so did Tracy Porter as he tried to tag the receiver. That allowed Benn, who spent the past three seasons on injured reserve, to get up and run untouched for his first touchdown in five seasons.
That gave the Jaguars a one-point lead with 2:49 left and sent the Bears (1-5) to another loss after they dropped the previous game to Indianapolis on a late TD pass by Andrew Luck.
Chicago came up short despite racking up 389 yards.